Structure of PDB 4b9d Chain A

Receptor sequence
>4b9dA (length=290) Species: 9606 (Homo sapiens) [Search protein sequence]
HHHHTENLYFQSMEKYVRLQKIKAILVKSTEDGRQYVIKEINISRMSSKE
REESRREVAVLANMKHPNIVQYRESFEENGSLYIVMDYCEGGDLFKRINA
QKGVLFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQL
GDFGIARVLNSTVELARACIGTPYYLSPEICENKPYNNKSDIWALGCVLY
ELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFKRNPR
DRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKTFSKFG
3D structure
PDB4b9d NEK1 kinase domain structure and its dynamic protein interactome after exposure to Cisplatin.
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D128 K130 Q132 N133 D146 S155 T166
Catalytic site (residue number reindexed from 1) D134 K136 Q138 N139 D152 S161 T172
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CK7 A A18 V31 Y82 C83 G86 D87 F135 A24 V37 Y88 C89 G92 D93 F141
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4b9d, PDBe:4b9d, PDBj:4b9d
PDBsum4b9d
PubMed28710492
UniProtQ96PY6|NEK1_HUMAN Serine/threonine-protein kinase Nek1 (Gene Name=NEK1)

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