Structure of PDB 4b99 Chain A

Receptor sequence
>4b99A (length=335) Species: 9606 (Homo sapiens) [Search protein sequence]
VTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNA
KRTLRELKILKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQ
IIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCEL
KIGDFGMARGLQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFG
EMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQRVRAYIQSLPPRQPVP
WETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPD
CAPPFDFAFDREALTRERIKEAIVAEIEDFHARRE
3D structure
PDB4b99 X-Ray Crystal Structure of Erk5 (Mapk7) in Complex with a Specific Inhibitor.
ChainA
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D182 K184 S186 N187 D200 T224
Catalytic site (residue number reindexed from 1) D136 K138 S140 N141 D154 T171
Enzyme Commision number 2.7.11.24: mitogen-activated protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 R4L A I61 N63 V69 I115 L137 D138 M140 E141 S142 Q146 L189 I15 N17 V23 I69 L91 D92 M94 E95 S96 Q100 L143 BindingDB: IC50=162nM,EC50=90nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004707 MAP kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4b99, PDBe:4b99, PDBj:4b99
PDBsum4b99
PubMed23656407
UniProtQ13164|MK07_HUMAN Mitogen-activated protein kinase 7 (Gene Name=MAPK7)

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