Structure of PDB 4b8s Chain A

Receptor sequence
>4b8sA (length=466) Species: 2265 (Thermococcus litoralis) [Search protein sequence]
KESLKDRIRLWKRLYVNAFENALNAIPNVKGVLLAYNTNIDAIKYLDKDD
LEKRVTEIGKEKVFEIIENPPEKISSIEELLGGILRSIKLGKAMEWFVES
EEVRRYLREWGWDELRIGGQAGIMANLLGGVYRIPTIVHVPQNPKLQAEL
FVDGPIYVPVFEGNKLKLVHPKDAIAEEEELIHYIYEFPRGFQVFDVQAP
RENRFIANADDYNARVYMRREFREGFEEITRNVELAIISGLQVLKEYYPD
GTTYRDVLDRVESHLNILNRYNVKSHFEFAYTANRRVREALVELLPKFTS
VGLNEVELASIMEIIGDEELAKEVLEGHIFSVIDAMNVLMDETGIERIHF
HTYGYYLALTQYRGEEVRDALLFASLAAAAKAMKGNLERIEQIRDALSVP
TNERAIVLEEELEKEFTEFENGLIDMVDRQLAFVPTKIVASPKSTVGIGD
TISSSAFVSEFGMRKR
3D structure
PDB4b8s Crystal Structure, Saxs and Kinetic Mechanism of Hyperthermophilic Adp-Dependent Glucokinase from Thermococcus Litoralis Reveal a Conserved Mechanism for Catalysis.
ChainA
Resolution2.58 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.-
2.7.1.147: ADP-specific glucose/glucosamine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLC A D42 E96 G119 G120 I124 H184 D451 D41 E95 G118 G119 I123 H183 D450
BS02 AMP A N305 H352 T353 V440 I449 I453 N304 H351 T352 V439 I448 I452
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004340 glucokinase activity
GO:0016301 kinase activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0043843 ADP-specific glucokinase activity
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006006 glucose metabolic process
GO:0006096 glycolytic process
GO:0016310 phosphorylation
GO:0051156 glucose 6-phosphate metabolic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4b8s, PDBe:4b8s, PDBj:4b8s
PDBsum4b8s
PubMed23818958
UniProtQ7M537|GLKA_THELN ADP-dependent glucose/glucosamine kinase (Gene Name=glkA)

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