Structure of PDB 4b7p Chain A

Receptor sequence
>4b7pA (length=214) Species: 9606 (Homo sapiens) [Search protein sequence]
MEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRY
ESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIA
KSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYA
WESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHS
QFIGYPITLFVEKE
3D structure
PDB4b7p Nms-E973, a Novel Synthetic Inhibitor of Hsp90 with Activity in Models of Drug Resistance to Targeted Agents, Including Intracranial Metastases.
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.10: non-chaperonin molecular chaperone ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9UN A N51 A55 K58 D93 I96 G97 M98 D102 N106 L107 T184 N40 A44 K47 D82 I85 G86 M87 D91 N95 L96 T173 MOAD: Kd=0.346nM
PDBbind-CN: -logKd/Ki=9.46,Kd=0.346nM
BindingDB: Kd=0.35nM
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0051082 unfolded protein binding
GO:0140662 ATP-dependent protein folding chaperone
Biological Process
GO:0006457 protein folding

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Molecular Function
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Biological Process
External links
PDB RCSB:4b7p, PDBe:4b7p, PDBj:4b7p
PDBsum4b7p
PubMed23674492
UniProtP07900|HS90A_HUMAN Heat shock protein HSP 90-alpha (Gene Name=HSP90AA1)

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