Structure of PDB 4b7j Chain A

Receptor sequence
>4b7jA (length=387) Species: 11320 (Influenza A virus) [Search protein sequence]
VKLAGNSSLCPVSGWAIYSKDNSIRIGSKGDVFVIREPFISCSPLECRTF
FLTQGALLNDKHSNGTIKDRSPYRTLMSCPIGEVPSPYNSRFESVAWSAS
ACHDGINWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNRLRTQESECA
CVNGSCFTVMTDGPSDGQASYKIFRIEKGKIVKSVEMNAPNYHYEECSCY
PDSSEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGIFGDNPRPNDKT
GSCGPVSSNGANGVKGFSFKYGNGVWIGRTKSISSRNGFEMIWDPNGWTG
TDNDFSIKQDIVGINEWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPK
ENTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTIDK
3D structure
PDB4b7j H1N1 2009 Pandemic Influenza Virus: Resistance of the I223R Neuraminidase Mutant Explained by Kinetic and Structural Analysis
ChainA
Resolution2.417 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D151 E278 R293 R368 Y402
Catalytic site (residue number reindexed from 1) D69 E196 R211 R286 Y320
Enzyme Commision number 3.2.1.18: exo-alpha-sialidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D294 G298 D324 G342 N344 D212 G216 D242 G260 N262
BS02 G39 A D151 R225 E277 R293 R368 Y402 D69 R143 E195 R211 R286 Y320 MOAD: Ki=11.1nM
PDBbind-CN: -logKd/Ki=7.95,Ki=11.1nM
Gene Ontology
Molecular Function
GO:0004308 exo-alpha-sialidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0046761 viral budding from plasma membrane
Cellular Component
GO:0016020 membrane
GO:0020002 host cell plasma membrane
GO:0033644 host cell membrane
GO:0044423 virion component
GO:0055036 virion membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4b7j, PDBe:4b7j, PDBj:4b7j
PDBsum4b7j
PubMed23028314
UniProtF8UU09

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