Structure of PDB 4b6c Chain A

Receptor sequence
>4b6cA (length=161) Species: 1772 (Mycolicibacterium smegmatis) [Search protein sequence]
STGERGLHHLIWEVVDNAVDEAMAGFATRVDVKIHADGSVEVRDDGRGIP
VPTIDVVMTQVGVSVVNALSTRLEATVLRDGYEWFQYYDRSVPGKLKQGG
ETKETGTTIRFWADPEIFETTDYNFETVARRLQEMAFLNKGLTIELTDER
DGKHRVFHYPG
3D structure
PDB4b6c Aminopyrazinamides: novel and specific GyrB inhibitors that kill replicating and nonreplicating Mycobacterium tuberculosis.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B5U A N52 E56 R82 G83 I84 P85 Q102 V123 S126 T169 N17 E21 R47 G48 I49 P50 Q60 V61 S64 T107 MOAD: ic50=0.69uM
PDBbind-CN: -logKd/Ki=6.16,IC50=0.69uM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:4b6c, PDBe:4b6c, PDBj:4b6c
PDBsum4b6c
PubMed23268609
UniProtP0C559|GYRB_MYCSM DNA gyrase subunit B (Gene Name=gyrB)

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