Structure of PDB 4b69 Chain A

Receptor sequence
>4b69A (length=448) [Search protein sequence]
RLRSTPQDELHDLLCVGFGPASLAIAIALHDALDPRLNKSAAQPKICFLE
RQKQFAWHSGMLVPGSKMQISFIKDLATLRDPRSSFTFLNYLHQKGRLIH
FTNLSTFLPARLEFEDYMRWCAQQFSDVVAYGEEVVEVIPGKSDPSSSVV
DFFTVRSRNVETGEISARRTRKVVIAIGGTAKMPSGLPQDPRIIHSSKYC
TTLPALLKDKSKPYNIAVLGSGQSAAEIFHDLQKRYPNSRTTLIMRDSAM
RPSDDSPFVNEIFNPERVDKFYSQSAAERQRSLLADKATNYSVVRLELIE
EIYNDMYLQRVKNPDETQWQHRILPERKITRVEHHGPQSRMRIHLKSSKP
KETLEVDALMVATGYNRNAHERLLSKVQHLRPTGQDQWKPHRDYRVEMDP
SKVSSEAGIWLQGCNERTHGLSDSLLSVLAVRGGEMVQSIFGEQLERA
3D structure
PDB4b69 Structural Insight Into the Mechanism of Oxygen Activation and Substrate Selectivity of Flavin-Dependent N-Hydroxylating Monooxygenases.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.13.196: L-ornithine N(5)-monooxygenase [NAD(P)H].
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A G46 G48 P49 A50 E83 R84 W90 H91 Q102 I103 E167 V168 A209 I210 G211 Y407 S466 L467 L468 G17 G19 P20 A21 E50 R51 W57 H58 Q69 I70 E134 V135 A176 I177 G178 Y365 S424 L425 L426
BS02 ORN A I103 K107 N293 F296 L467 S469 I70 K74 N260 F263 L425 S427
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004497 monooxygenase activity
GO:0004499 N,N-dimethylaniline monooxygenase activity
GO:0005506 iron ion binding
GO:0031172 ornithine N5-monooxygenase activity
GO:0070401 NADP+ binding
Biological Process
GO:0006696 ergosterol biosynthetic process
GO:0006879 intracellular iron ion homeostasis
GO:0009058 biosynthetic process
GO:0010106 cellular response to iron ion starvation
GO:0019290 siderophore biosynthetic process
GO:0031169 ferrichrome biosynthetic process
GO:0033214 siderophore-dependent iron import into cell
GO:0044550 secondary metabolite biosynthetic process
Cellular Component
GO:0005575 cellular_component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4b69, PDBe:4b69, PDBj:4b69
PDBsum4b69
PubMed22928747
UniProtE9QYP0|SIDA_ASPFU L-ornithine N(5)-monooxygenase (Gene Name=sidA)

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