Structure of PDB 4b65 Chain A

Receptor sequence

>4b65A (length=456) Species: 746128 (Aspergillus fumigatus) [Search protein sequence]

PRLRSTPQDELHDLLCVGFGPASLAIAIALHDALDPRLNKSASNIHAQPK
ICFLERQKQFAWHSGMLVPGSKMQISFIKDLATLRDPRSSFTFLNYLHQK
GRLIHFTNLSTFLPARLEFEDYMRWCAQQFSDVVAYGEEVVEVIPGKSDP
SSSVVDFFTVRSRNVETGEISARRTRKVVIAIGGTAKMPSGLPQDPRIIH
SSKYCTTLPALLKDKSKPYNIAVLGSGQSAAEIFHDLQKRYPNSRTTLIM
RDSAMRPSDDSPFVNEIFNPERVDKFYSQSAAERQRSLLADKATNYSVVR
LELIEEIYNDMYLQRVKNPDETQWQHRILPERKITRVEHHGPQSRMRIHL
KSSKPEVKETLEVDALMVATGYNRNAHERLLSKVQHLRPTGQDQWKPHRD
YRVEMDPSKVSSEAGIWLQGCNERTHGLSDSLLSVLAVRGGEMVQSIFGE
QLERAA

3D structure

PDB

4b65 Structural Insight Into the Mechanism of Oxygen Activation and Substrate Selectivity of Flavin-Dependent N-Hydroxylating Monooxygenases.

Chain

Resolution

2.32 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.14.13.196: L-ornithine N(5)-monooxygenase [NAD(P)H].

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	A	G46 G48 P49 A50 L82 E83 R84 Q85 W90 H91 M101 I103 R144 E167 V168 I210 G211 S466 L468	G18 G20 P21 A22 L54 E55 R56 Q57 W62 H63 M73 I75 R116 E139 V140 I182 G183 S431 L433
BS02	NDP	A	K100 Q102 R144 K215 P217 S254 G255 Q256 S257 E260 R279 N323 S325 A404 T405 G406	K72 Q74 R116 K187 P189 S226 G227 Q228 S229 E232 R251 N295 S297 A369 T370 G371

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0004497	monooxygenase activity
GO:0004499	N,N-dimethylaniline monooxygenase activity
GO:0005506	iron ion binding
GO:0031172	ornithine N5-monooxygenase activity
GO:0070401	NADP+ binding

	Biological Process
GO:0006696	ergosterol biosynthetic process
GO:0006879	intracellular iron ion homeostasis
GO:0009058	biosynthetic process
GO:0010106	cellular response to iron ion starvation
GO:0019290	siderophore biosynthetic process
GO:0031169	ferrichrome biosynthetic process
GO:0033214	siderophore-dependent iron import into cell
GO:0044550	secondary metabolite biosynthetic process

	Cellular Component
GO:0005575	cellular_component

View graph for
Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:4b65, PDBe:4b65, PDBj:4b65
PDBsum	4b65
PubMed	22928747
UniProt	E9QYP0\|SIDA_ASPFU L-ornithine N(5)-monooxygenase (Gene Name=sidA)

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