Structure of PDB 4b52 Chain A

Receptor sequence

>4b52A (length=304) Species: 1406 (Paenibacillus polymyxa)

ATGTGKGVLGDTKSFTTTASGSSYQLKDTTRGNGVVTYTASNRQSIPGTI
LTDADNVWNDPAGVDAHTYAAKTYDYYKAKFGRNSIDGRGLQLRSTVHYG
SRYNNAFWNGSQMTYGDGDGSTFIAFSGDPDVVGHELTHGVTEYTSNLEY
YGESGALNEAFSDVIGNDIQRKNWLVGDDIYTPNIAGDALRSMSNPTLYD
QPDHYSNLYTGSSDNGGVHTNSGIINKAYYLLAQGGTFHGVTVNGIGRDA
AVQIYYSAFTNYLTSSSDFSNARAAVIQAAKDQYGANSAEATAAAKSFDA
VGVN

3D structure

• PDB: 4b52 Structure of Gentlyase, the Neutral Metalloprotease of Paenibacillus Polymyxa
• Chain: A
• Resolution: 1.76 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): H135 E136 H139 Y150 E159 D214 H219
• Catalytic site (residue number reindexed from 1): H135 E136 H139 Y150 E159 D214 H219
• Enzyme Commision number: 3.4.24.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	A	H135 H139 E159	H135 H139 E159
BS02	CA	A	D129 D131 Q170 D178 D179	D129 D131 Q170 D178 D179
BS03	CA	A	D53 D55 V57	D53 D55 V57
BS04	CA	A	Y181 T182 I185 D188	Y181 T182 I185 D188
BS05	RDF	A	N104 N105 A106 F123 F126 H135 E136 H139 E159 L190 R191 H219	N104 N105 A106 F123 F126 H135 E136 H139 E159 L190 R191 H219
BS06	RDF	A	Y151 N215	Y151 N215

Gene Ontology

Molecular Function

• GO:0004222 metalloendopeptidase activity

Biological Process

• GO:0006508 proteolysis

External links

• PDB: RCSB:4b52, PDBe:4b52, PDBj:4b52
• PDBsum: 4b52
• PubMed: 23275160
• UniProt: E3E6L0