Structure of PDB 4b3g Chain A

Receptor sequence
>4b3gA (length=614) Species: 9606 (Homo sapiens) [Search protein sequence]
AAVESFVTKQLDLLELERDAEVEERRSWLKELQSRGVCLLKLQVSSQRTG
LYGRLLVTFEPRRYGSAAALPSNSFTSGDIVGLYDGSQLATGILTRVTQK
SVTVAFDEQQSLDRENSYRLLKLANDVTYRRLKKALIALKKYHSGPASSL
IEVLFGRSAPSPASEIHPLTFFNTCLDTSQKEAVLFALSQKELAIIHGPP
GTGKTTTVVEIILQAVKQGLKVLCCAPSNIAVDNLVERLALCKQRILRLG
HPARLLESIQQHSLDAVLARSDSAQIVADIRKDIDQVFVKNNEIKLLRKE
LKEREEAAMLESLTSANVVLATNTGASADGPLKLLPESYFDVVVIDECAQ
ALEASCWIPLLKARKCILAGDHKQLPPTTVSHKAALAGLSLSLMERLAEE
YGARVVRTLTVQYRMHQAIMRWASDTMYLGQLTAHSSVARHLLRDLPGVA
ATEETGVPLLLVDTAGCGLFELQSKGNPGEVRLVSLHIQALVDAGVPARD
IAVVSPYNLQVDLLRQSLVHRHPELEIKSVDGFQGREKEAVILSFVRSNR
KGEVGFLAEDRRINVAVTRARRHVAVICDSRTVNNHAFLKTLVEYFTQHG
EVRTAFEYLDDIVP
3D structure
PDB4b3g The Ighmbp2 Helicase Structure Reveals the Molecular Basis for Disease-Causing Mutations in Dmsa1.
ChainA
Resolution2.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A G86 D87 N141 V143 T144 R147 P243 S244 N245 R270 T351 T353 T407 H411 Q507 S508 Y541 N542 D565 G589 F590 G78 D79 N125 V127 T128 R131 P227 S228 N229 R254 T322 T324 T378 H382 Q473 S474 Y507 N508 D531 G555 F556
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:4b3g, PDBe:4b3g, PDBj:4b3g
PDBsum4b3g
PubMed22965130
UniProtP38935|SMBP2_HUMAN DNA-binding protein SMUBP-2 (Gene Name=IGHMBP2)

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