Structure of PDB 4b2z Chain A

Receptor sequence
>4b2zA (length=399) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
DTDDIDEDDESGHNIILNIISQLRPGCDLTRITLPTFILEKKSMLERVTN
QLQFPEFLLQAHSEKDPLKRFLYVMKWYLAGWHIAPKAVKKPLNPVLGEY
FTAYWDLPNKQQAYYISEQTSHHPPECAYFYMIPESSIRVDGVVIPKSRF
LGNSSAAMMDGSTVLQFLDIKDGNGKPEKYVLTQPNVYVRGILFGKMRIE
LGDHMIIKSPNFQADIEFKTKGYVFGTYDAIEGTVKDYDGNAYYEISGKW
NDVMYLKDLKQPRSSPKVFLDTHKESPLRPKVRPLSEQGEYESRKLWKKV
TDALAVRNHPVATEEKFQIEDHQRQLAKKRIEDGVEFHPKLFRRSKPGED
LDYCIYKNIPVDEDPEKQIRSILQIAPILPGQQFTDKFFIPAFEKIKSQ
3D structure
PDB4b2z Interactome Map Uncovers Phosphatidylserine Transport by Oxysterol-Binding Proteins
ChainA
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 P5S A L64 I67 L69 I73 M79 R82 Q86 L87 W112 Y113 K125 K126 P127 N129 S183 A191 A192 M194 V222 M232 I234 L29 I32 L34 I38 M44 R47 Q51 L52 W77 Y78 K90 K91 P92 N94 S148 A156 A157 M159 V187 M197 I199
Gene Ontology
Molecular Function
GO:0001786 phosphatidylserine binding
GO:0005548 phospholipid transporter activity
GO:0008289 lipid binding
GO:0010314 phosphatidylinositol-5-phosphate binding
GO:0032934 sterol binding
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding
GO:0070273 phosphatidylinositol-4-phosphate binding
GO:0070300 phosphatidic acid binding
GO:0080025 phosphatidylinositol-3,5-bisphosphate binding
GO:0120015 sterol transfer activity
Biological Process
GO:0006869 lipid transport
GO:0006887 exocytosis
GO:0006897 endocytosis
GO:0015914 phospholipid transport
GO:0015918 sterol transport
GO:0016125 sterol metabolic process
GO:0030011 maintenance of cell polarity
GO:0034727 piecemeal microautophagy of the nucleus
GO:0055092 sterol homeostasis
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0032541 cortical endoplasmic reticulum

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4b2z, PDBe:4b2z, PDBj:4b2z
PDBsum4b2z
PubMed23934110
UniProtQ02201|OSH6_YEAST Oxysterol-binding protein homolog 6 (Gene Name=OSH6)

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