Structure of PDB 4b1j Chain A

Receptor sequence
>4b1jA (length=508) Species: 9606 (Homo sapiens) [Search protein sequence]
KKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPT
HYKDLWDNKHVKMPCSEQNLYPVERTAGSRWELIQTALLNKFTRPQNLKD
AILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLP
NICTQPIPLLAAAMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSS
YPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTAAAPTGLVTFTRQSLEDF
PEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQE
EIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSH
EDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRP
GVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDS
ELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPF
IYHAVESC
3D structure
PDB4b1j Structures of the Human Poly (Adp-Ribose) Glycohydrolase Catalytic Domain Confirm Catalytic Mechanism and Explain Inhibition by Adp-Hpd Derivatives.
ChainA
Resolution2.08 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.143: poly(ADP-ribose) glycohydrolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1R A I726 E727 F738 N740 V753 Q754 E755 E756 Y795 N869 G871 G873 A874 F875 F902 I271 E272 F283 N285 V298 Q299 E300 E301 Y340 N414 G416 G418 A419 F420 F447 PDBbind-CN: -logKd/Ki=7.30,Kd=50.0nM
BindingDB: IC50=120nM
Gene Ontology
Molecular Function
GO:0004649 poly(ADP-ribose) glycohydrolase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006282 regulation of DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4b1j, PDBe:4b1j, PDBj:4b1j
PDBsum4b1j
PubMed23251397
UniProtQ86W56|PARG_HUMAN Poly(ADP-ribose) glycohydrolase (Gene Name=PARG)

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