Structure of PDB 4b18 Chain A

Receptor sequence
>4b18A (length=427) Species: 9606 (Homo sapiens) [Search protein sequence]
PGGVITSDMIEMIFSKSPEQQLSATQKFRKLLSKEPNPPIDEVISTPGVV
ARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRIVIQAGAVPIFIELL
SSEFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPLLQLFSKQNRLTM
TRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVSDTDVLADACWAL
SYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDD
IQTQVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVID
ANIFPALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIKPL
CDLLTVMDSKIVQVALNGLENILRLGEQEAKRNGTGINPYCALIEEAYGL
DKIEFLQSHENQEIYQKAFDLIEHYFG
3D structure
PDB4b18 Akt-Mediated Phosphorylation Increases the Binding Affinity of Htert for Importin Alpha to Promote Nuclear Translocation.
ChainA
Resolution2.52 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A E113 W149 N153 A155 G157 T162 Q188 W191 N195 G198 D199 W234 R241 W276 G284 R318 T325 K356 E357 R395 E399 W402 E35 W71 N75 A77 G79 T84 Q110 W113 N117 G120 D121 W156 R163 W198 G206 R240 T247 K278 E279 R317 E321 W324
Gene Ontology
Molecular Function
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0006606 protein import into nucleus
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4b18, PDBe:4b18, PDBj:4b18
PDBsum4b18
PubMed25999477
UniProtP52294|IMA5_HUMAN Importin subunit alpha-5 (Gene Name=KPNA1)

[Back to BioLiP]