Structure of PDB 4azt Chain A

Receptor sequence
>4aztA (length=435) Species: 562 (Escherichia coli) [Search protein sequence]
DLNTLVSELPEIYQTIFGHPEWDGDAARDCNQRLDLITEQYDNLSRALGR
PLNVLDLGCAQGFFSLSLASKGATIVGIDFQQENINVCRALAEENPDFAA
EFRVGRIEEVIAALEEGEFDLAIGLSVFHHIVHLHGIDEVKRLLSRLADV
TQAVILELAVKEEPFYWGVSQPDDPRELIEQCAFYRLIGEFDTHLSPVPR
PMYLVSNHRVLINDFNQPFQHWQNRSRRYFFGEDYVCKFFYYDMPHGILT
AEESQRNKYELHNEIKFLTQPPAGFDAPAVLAHGENAQSGWLVMEKLPGR
LLSDMLAAGEEIDREKILGSLLRSLAALEKQGFWHDDVRPWNVMVDARQH
ARLIDFGSIVTTSWPTNLVQSFFVFVNELFNLPQPWSNWLYAVWQEPVER
WNFVLLLALFEKKAKLPSAEQQRGATEQWIIAQET
3D structure
PDB4azt Structure of Wbdd; a Bifunctional Kinase and Methyltransferase that Regulates the Chain Length of the O Antigen in Escherichia Coli O9A.
ChainA
Resolution2.34 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.294: 3-O-phospho-polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol 3-phospho-methyltransferase.
2.7.1.181: polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAM A Y16 Q17 R36 G61 A63 D82 F83 Q84 N87 R109 I110 L128 S129 V130 Y13 Q14 R33 G58 A60 D79 F80 Q81 N84 R106 I107 L125 S126 V127
BS02 LY2 A Y243 F245 V250 L311 M358 Y229 F231 V236 L297 M344 MOAD: ic50=68uM
PDBbind-CN: -logKd/Ki=4.17,IC50=68uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4azt, PDBe:4azt, PDBj:4azt
PDBsum4azt
PubMed22970759
UniProtQ47592|WBDD2_ECOLX O-antigen chain terminator bifunctional methyltransferase/kinase WbdD (Gene Name=wbdD)

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