Structure of PDB 4azs Chain A

Receptor sequence
>4azsA (length=442) Species: 562 (Escherichia coli) [Search protein sequence]
DLNTLVSELPEIYQTIFGHPEWDGDAARDCNQRLDLITEQYDNLSRALGR
PLNVLDLGCAQGFFSLSLASKGATIVGIDFQQENINVCRALAEENPDFAA
EFRVGRIEEVIAALEEGEFDLAIGLSVFHHIVHLHGIDEVKRLLSRLADV
TQAVILELAVKEEPFYWGVSQPDDPRELIEQCAFYRLIGEFDTHLSPVPR
PMYLVSNHRVLINDFNQPFQHWQNQPYRSRRYFFGEDYVCKFFYYDMPHG
ILTAEESQRNKYELHNEIKFLTQPPAGFDAPAVLAHGENAQSGWLVMEKL
PGRLLSDMLAAGEEIDREKILGSLLRSLAALEKQGFWHDDVRPWNVMVDA
RQHARLIDFGSIVTTPSWPTNLVQSFFVFVNELFFNLPQPWSNWLYAVWQ
EPVERWNFVLLLALFEKKAKLPSAEQQRGATEQWIIAQETVL
3D structure
PDB4azs Structure of Wbdd; a Bifunctional Kinase and Methyltransferase that Regulates the Chain Length of the O Antigen in Escherichia Coli O9A.
ChainA
Resolution2.15 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.1.1.294: 3-O-phospho-polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol 3-phospho-methyltransferase.
2.7.1.181: polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AMP A Q226 P229 Y243 F245 V250 K310 L311 L315 M358 I368 Q223 P226 Y232 F234 V239 K299 L300 L304 M347 I357
BS02 SAM A Y16 Q17 R36 G61 A63 D82 F83 Q84 R109 I110 L128 S129 V130 Y13 Q14 R33 G58 A60 D79 F80 Q81 R106 I107 L125 S126 V127
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4azs, PDBe:4azs, PDBj:4azs
PDBsum4azs
PubMed22970759
UniProtQ47592|WBDD2_ECOLX O-antigen chain terminator bifunctional methyltransferase/kinase WbdD (Gene Name=wbdD)

[Back to BioLiP]