Structure of PDB 4az3 Chain A

Receptor sequence
>4az3A (length=259) Species: 9606 (Homo sapiens) [Search protein sequence]
RAPDQDEIQRLPGLAKQPSFRQYSGYLKGSGSKHLHYWFVESQKDPENSP
VVLWLNGGPGCSSLDGLLTEHGPFLVQPDGVTLEYNPYSWNLIANVLYLE
SPAGVGFSYSDDKFYATNDTEVAQSNFEALQDFFRLFPEYKNNKLFLTGE
SYAGIYIPTLAVLVMQDPSMNLQGLAVGNGLSSYEQNDNSLVYFAYYHGL
LGNRLWSSLQTHCCSQNKCNFYDNKDLECVTNLQEVARIVGNSGLNIYNL
YAPCAGGVP
3D structure
PDB4az3 Novel Beta-Amino Acid Derivatives as Inhibitors of Cathepsin A.
ChainA
Resolution2.04 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G57 S150 Y151
Catalytic site (residue number reindexed from 1) G58 S151 Y152
Enzyme Commision number 3.4.16.5: carboxypeptidase C.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 S35 A N55 G56 G57 C60 D64 E149 S150 Y247 N56 G57 G58 C61 D65 E150 S151 Y248 MOAD: ic50=0.005uM
PDBbind-CN: -logKd/Ki=8.30,IC50=0.005uM
BindingDB: IC50=5nM
Gene Ontology
Molecular Function
GO:0004185 serine-type carboxypeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:4az3, PDBe:4az3, PDBj:4az3
PDBsum4az3
PubMed22861813
UniProtP10619|PPGB_HUMAN Lysosomal protective protein (Gene Name=CTSA)

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