Structure of PDB 4ay6 Chain A

Receptor sequence
>4ay6A (length=698) Species: 9606 (Homo sapiens) [Search protein sequence]
SCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVL
QQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRA
IQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAH
CLQIVCDWTDYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYPLSHGFRK
AIAERHGNLCLDKINVLHKPPYEHPKDLKLSDGRLRVGYVSSDFGNHPTS
HLMQSIPGMHNPDKFEVFCYALSPDDGTNFRVKVMAEANHFIDLSQIPCN
GKAADRIHQDGIHILVNMNGYTKGARNELFALRPAPIQAMWLGYPGTSGA
LFMDYIITDQETSPAEVAEQYSEKLAYMPHTFFIGDHANMFPHLKKKAVI
DFKIYDNRIVLNGIDLKAFLDSLPDVKIVKMLNMPVIPMNTIAEAVIEMI
NRGQIQITINGFSISNGLATTQINNKAATGEEVPRTIIVTTRSQYGLPED
AIVYCNFNQLYKIDPSTLQMWANILKRVPNSVLWLLRFPAVGEPNIQQYA
QNMGLPQNRIIFSPVAPKEEHVRRGQLADVCLDTPLCNGHTTGMDVLWAG
TPMVTMPGETLASRVAASQLTCLGCLELIAKNRQEYEDIAVKLGTDLEYL
KKVRGKVWKQRISSPLFNTKQYTMELERLYLQMWEHYAAGNKPDHMIK
3D structure
PDB4ay6 O-Glcnac Transferase Invokes Nucleotide Sugar Pyrophosphate Participation in Catalysis
ChainA
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.255: protein O-GlcNAc transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A H496 H499 N557 T633 A636 Q839 V895 H185 H188 N246 T322 A325 Q509 V565
BS02 12V A H498 P559 T560 G654 P656 Q839 K842 L866 A896 K898 H901 H920 T921 T922 D925 H187 P248 T249 G343 P345 Q509 K512 L536 A566 K568 H571 H590 T591 T592 D595 PDBbind-CN: -logKd/Ki=5.12,Kd=7.5uM
External links
PDB RCSB:4ay6, PDBe:4ay6, PDBj:4ay6
PDBsum4ay6
PubMed23103942
UniProtO15294|OGT1_HUMAN UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (Gene Name=OGT)

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