Structure of PDB 4ay2 Chain A

Receptor sequence

>4ay2A (length=628) Species: 9606 (Homo sapiens)

PFKPRNYQLELALPAMKGKNTIICAPTGCGKTFVSLLICEHHLKKFPQGQ
KGKVVFFANQIPVYEQNKSVFSKYFERHGYRVTGISGATAENVPVEQIVE
NNDIIILTPQILVNNLKKGTIPSLSIFTLMIFDECHNTSKQHPYNMIMFN
YLDQKLGGSSGPLPQVIGLTASVGVGDAKNTDEALDYICKLCASLDASVI
ATVKHNLEELEQVVYKPQKFFRKVESRISDKFKYIIAQLMRDTESLAKRI
CKDLENLSQIQNREFGTQKYEQWIVTVQKACMVEESRICKALFLYTSHLR
KYNDALIISEHARMKDALDYLKDFFSNVRAAGFDEIEQDLTQRFEEKLQE
LESVSRDPSNENPKLEDLCFILQEEYHLNPETITILFVKTRALVDALKNW
IEGNPKLSFLKPGILGDHNILIATSVADEAQCNLVILYEYVSKCFLLTSN
AGVIEKEQINMYKEKMMNDSILRLQTWDEAVFREKILHIQTHEKFIRDSQ
EKPKPVPDKENKKLLCRKCKALACYTADVRVIEDCHYTVLGDAFKECFVS
RPHPKPKQFSSFEKRAKIFCARQNCSHDWGIHVKYKTFEIPVIKIESFVV
EDIATGVQTLYSKWKDFHFEKIPFDPAE

3D structure

• PDB: 4ay2 Visualizing the Determinants of Viral RNA Recognition by Innate Immune Sensor Rig-I.
• Chain: A
• Resolution: 2.8 Å

Enzymatic activity

• Enzyme Commision number: 3.6.4.13: RNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	Q299 I300 G326 T347 Q349 K379 Q380 H381 I499 N501 Q511 C829 H830 F853 K858 K861 I875 K888 S906	Q60 I61 G87 T108 Q110 K140 Q141 H142 I260 N262 Q272 C535 H536 F559 K564 K567 I581 K594 S612
BS02	ZN	A	C810 C864 C869	C516 C570 C575
BS03	ADP	A	R244 Q247 T266 G267 G269 K270 T271	R5 Q8 T27 G28 G30 K31 T32

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0005524 ATP binding

External links

• PDB: RCSB:4ay2, PDBe:4ay2, PDBj:4ay2
• PDBsum: 4ay2
• PubMed: 23022350
• UniProt: O95786|RIGI_HUMAN Antiviral innate immune response receptor RIG-I (Gene Name=RIGI)