Structure of PDB 4axe Chain A

Receptor sequence
>4axeA (length=428) Species: 3702 (Arabidopsis thaliana) [Search protein sequence]
MEMILEEKDASDWIYRGEGGANLVLAYAGSSPLFVGKVIRIQKARRNDKA
IKNSNGVVSVLTSDEQHLWRENNELISSPNKEVLEQRYVQNVIIPLLGPK
HVDAGVRVSVSKEFLECVDKKVTKQRPLWRVNAANVDTSHDSALILNDHS
LFSQGITGDCISVEIKPKCGFLPTSRFIGKENMLKTSVSRFKMHQLLKLE
YIEISEESEYDPLDLFSGSKERVLEAIKALYSTPQNNFRVFLNGSLILGG
SGESTGRTSPEIGYAFEDALKGFIQSEDGHRTECFLQLVSDAVYGSGVLD
RLLEIQKLDKLDIEGAIHCYYDIINQPCPICRPLEAELSLHALPLDESLK
IVKEYLIAATAKDCSIMISFQSRNAWDSEPGDYVSLKPTNQTFDYKVHFI
DLSLKPLKRMESYYKLDKKIISFYNRKQ
3D structure
PDB4axe Conformational Changes Undergone by Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase Upon Substrate Binding: The Role of N-Lobe and Enantiomeric Substrate Preference
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.158: inositol-pentakisphosphate 2-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A E18 G19 A21 N22 V24 R40 N147 D148 H149 E166 M372 I406 D407 E18 G19 A21 N22 V24 R40 N147 D148 H149 E164 M367 I400 D401
BS02 ZN A H320 C330 H346 H318 C328 H341
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0032942 inositol-1,4,5,6-tetrakisphosphate 2-kinase activity
GO:0035299 inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity
GO:0046872 metal ion binding
GO:0102731 inositol-1,3,4,6-tetrakisphosphate 2-kinase activity
Biological Process
GO:0010264 myo-inositol hexakisphosphate biosynthetic process
GO:0016310 phosphorylation
GO:0030643 intracellular phosphate ion homeostasis
GO:0042742 defense response to bacterium
GO:0048527 lateral root development
GO:0050832 defense response to fungus
GO:0051607 defense response to virus
GO:0055062 phosphate ion homeostasis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4axe, PDBe:4axe, PDBj:4axe
PDBsum4axe
PubMed22745128
UniProtQ93YN9|IPPK_ARATH Inositol-pentakisphosphate 2-kinase (Gene Name=IPK1)

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