Structure of PDB 4ax8 Chain A

Receptor sequence
>4ax8A (length=450) Species: 562 (Escherichia coli) [Search protein sequence]
DLNTLVSELPEIYQTIFGHPEWDGDAARDCNQRLDLITEQYDNLSRALGR
PLNVLDLGCAQGFFSLSLASKGATIVGIDFQQENINVCRALAEENPDFAA
EFRVGRIEEVIAALEEGEFDLAIGLSVFHHIVHLHGIDEVKRLLSRLADV
TQAVILELAVKEEPFYWGVSQPDDPRELIEQCAFYRLIGEFDTHLSPVPR
PMYLVSNHRVLINDFNQPFQHWQNQPYAGAGLAHKRSRRYFFGEDYVCKF
FYYDMPHGILTAEESQRNKYELHNEIKFLTQPPAGFDAPAVLAHGENAQS
GWLVMEKLPGRLLSDMLAAGEEIDREKILGSLLRSLAALEKQGFWHDDVR
PWNVMVDARQHARLIDFGSIVTTPSWPTNLVQSFFVFVNELFFNLPQPWS
NWLYAVWQEPVERWNFVLLLALFEKKAKLPSAEQQRGATEQWIIAQETVL
3D structure
PDB4ax8 Crystallization, Dehydration and Experimental Phasing of Wbdd, a Bifunctional Kinase and Methyltransferase from Escherichia Coli O9A.
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.294: 3-O-phospho-polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol 3-phospho-methyltransferase.
2.7.1.181: polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAM A Y16 Q17 R36 G61 A63 D82 F83 N87 R109 I110 E111 L128 S129 V130 Y13 Q14 R33 G58 A60 D79 F80 N84 R106 I107 E108 L125 S126 V127
BS02 ADP A P229 R241 Y243 V250 K252 I368 D369 P226 R238 Y240 V247 K249 I365 D366
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4ax8, PDBe:4ax8, PDBj:4ax8
PDBsum4ax8
PubMed22993091
UniProtJ7I4B7|WBDD_ECOLX O-antigen chain terminator bifunctional methyltransferase/kinase WbdD (Gene Name=wbdD)

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