Structure of PDB 4awp Chain A

Receptor sequence
>4awpA (length=204) Species: 9606 (Homo sapiens) [Search protein sequence]
VETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTD
PSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTK
AFMEALQDISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGS
FTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPIT
LFVE
3D structure
PDB4awp Discovery of Xl888: A Novel Tropane-Derived Small Molecule Inhibitor of Hsp90.
ChainA
Resolution1.82 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.10: non-chaperonin molecular chaperone ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 99A A F22 Q23 N51 M98 L103 I104 N106 L107 F138 Y139 W162 F170 F6 Q7 N35 M82 L87 I88 N90 L91 F119 Y120 W143 F151 MOAD: ic50=81nM
PDBbind-CN: -logKd/Ki=7.09,IC50=81nM
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0051082 unfolded protein binding
GO:0140662 ATP-dependent protein folding chaperone
Biological Process
GO:0006457 protein folding

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Molecular Function
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Biological Process
External links
PDB RCSB:4awp, PDBe:4awp, PDBj:4awp
PDBsum4awp
PubMed22877636
UniProtP07900|HS90A_HUMAN Heat shock protein HSP 90-alpha (Gene Name=HSP90AA1)

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