Structure of PDB 4awk Chain A

Receptor sequence

>4awkA (length=174) Species: 641501 (Influenza A virus (A/California/04/2009(H1N1)))

AMEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFMYS
DFGHRFEIIEGRDRIMAWTVVNSICNTTGVEKPKFLPDLYDYKENRFIEI
GVTRREVHIYYLEKANKIKEKTHIHIFSFTGEEMATKADYTLDEESRARI
KTRLFTIRQEMASRSLWDSFRQSE

3D structure

• PDB: 4awk Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza Ph1N1 (2009) Polymerase.
• Chain: A
• Resolution: 1.9 Å

Enzymatic activity

• Enzyme Commision number: 3.1.-.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CI1	A	A20 E23 Y24 E26 K34 I38 H41 E80 R84 L106 D108 E119 K134	A21 E24 Y25 E27 K35 I39 H42 E60 R64 L86 D88 E99 K114	MOAD: ic50=0.13uM PDBbind-CN: -logKd/Ki=6.89,IC50=0.13uM
BS02	MN	A	H41 D108 E119 I120	H42 D88 E99 I100
BS03	MN	A	E80 D108	E60 D88

Gene Ontology

Molecular Function

• GO:0003723 RNA binding

Biological Process

• GO:0039694 viral RNA genome replication

External links

• PDB: RCSB:4awk, PDBe:4awk, PDBj:4awk
• PDBsum: 4awk
• PubMed: 22876177
• UniProt: C3W5S0