Structure of PDB 4awg Chain A

Receptor sequence

>4awgA (length=187) Species: 641501 (Influenza A virus (A/California/04/2009(H1N1)))

GMAMEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFM
YSDFHFIDERGESIIVELLKHRFEIIEGRDRIMAWTVVNSICNTTGVEKP
KFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKKTHIHIFSFTGEEMAT
KADYTLDEESRARIKTRLFTIRQEMASRSLWDSFRQS

3D structure

• PDB: 4awg Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza Ph1N1 (2009) Polymerase.
• Chain: A
• Resolution: 2.6 Å

Enzymatic activity

• Enzyme Commision number: 3.1.-.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CI3	A	E23 Y24 A37 I38 H41 E80 R84 D108 E119 K134	E26 Y27 A40 I41 H44 E77 R81 D105 E116 K131	PDBbind-CN: -logKd/Ki=5.96,IC50=1.1uM
BS02	MN	A	H41 D108 E119 I120	H44 D105 E116 I117
BS03	MN	A	E80 D108	E77 D105

Gene Ontology

Molecular Function

• GO:0003723 RNA binding

Biological Process

• GO:0039694 viral RNA genome replication

External links

• PDB: RCSB:4awg, PDBe:4awg, PDBj:4awg
• PDBsum: 4awg
• PubMed: 22876177
• UniProt: C3W5S0