Structure of PDB 4awf Chain A

Receptor sequence
>4awfA (length=191) Species: 641501 (Influenza A virus (A/California/04/2009(H1N1))) [Search protein sequence]
SGMAMEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCF
MYSDFHFISIIVEPNALLKHRFEIIEGRDRIMAWTVVNSICNTTGVEKPK
FLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKTHIHIFSFTGEEMAT
KADYTLDEESRARIKTRLFTIRQEMASRSLWDSFRQSERGE
3D structure
PDB4awf Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza Ph1N1 (2009) Polymerase.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A E80 D108 E76 D104
BS02 MN A H41 D108 E119 I120 H45 D104 E115 I116
BS03 XI7 A H41 R84 D108 E119 K134 H45 R80 D104 E115 K130 MOAD: ic50=2.7uM
PDBbind-CN: -logKd/Ki=5.57,IC50=2.7uM
Gene Ontology
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:4awf, PDBe:4awf, PDBj:4awf
PDBsum4awf
PubMed22876177
UniProtC3W5S0

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