Structure of PDB 4aw5 Chain A

Receptor sequence
>4aw5A (length=261) Species: 9606 (Homo sapiens) [Search protein sequence]
AKEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTER
QRREFLSEASIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLR
LNDGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKV
SDFGIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQ
DVINAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSALDKM
IRNPASLKIVA
3D structure
PDB4aw5 The Design, Synthesis, and Biological Evaluation of Potent Receptor Tyrosine Kinase Inhibitors.
ChainA
Resolution2.33 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D216 A218 R220 N221 D234 P259
Catalytic site (residue number reindexed from 1) D134 A136 R138 N139 D152 P156
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 30K A I97 A121 K123 M172 E173 G175 L223 I15 A39 K41 M90 E91 G93 L141 MOAD: ic50=765nM
PDBbind-CN: -logKd/Ki=6.12,IC50=765nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4aw5, PDBe:4aw5, PDBj:4aw5
PDBsum4aw5
PubMed22765894
UniProtP54760|EPHB4_HUMAN Ephrin type-B receptor 4 (Gene Name=EPHB4)

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