Structure of PDB 4aw2 Chain A

Receptor sequence
>4aw2A (length=398) Species: 10116 (Rattus norvegicus) [Search protein sequence]
SGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREK
NILEYLEWAKPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADK
VFAMKILNKWEMLKRAETACFREERDVLVNGDSKWITTLHYAFQDDNNLY
LVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVIAIDSVHQLHYVHRD
IKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQA
MEGGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERF
QFPTQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNI
RNCEAPYIPEVSSPTDTSNFDVDSGHHLPFVGFTYTSSCVLSDRSCLR
3D structure
PDB4aw2 Cdc42 Binding Protein Kinase Alpha (Mrck Alpha)
ChainA
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D201 K203 N206 D219 T240
Catalytic site (residue number reindexed from 1) D200 K202 N205 D218 T239
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 22E A D33 I36 K68 R71 H73 Q145 D146 D147 D32 I35 K67 R70 H72 Q144 D145 D146
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4aw2, PDBe:4aw2, PDBj:4aw2
PDBsum4aw2
PubMed
UniProtO54874|MRCKA_RAT Serine/threonine-protein kinase MRCK alpha (Gene Name=Cdc42bpa)

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