Structure of PDB 4aw1 Chain A

Receptor sequence
>4aw1A (length=284) Species: 9606 (Homo sapiens) [Search protein sequence]
QHAQPPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHI
IKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELL
KYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMH
IQITDFGTAKVLARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQ
LVAGLPPFRAGNEGLIFAKIIKLEYDFPEKFFPKARDLVEKLLVLDATKR
LGCEEMEGYGPLKAHPFFESVTWENLHQQTPPKL
3D structure
PDB4aw1 Substrate-Selective Inhibition of Protein Kinase Pdk1 by Small Compounds that Bind to the Pif-Pocket Allosteric Docking Site.
ChainA
Resolution1.68 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D205 K207 E209 N210 D223 T245
Catalytic site (residue number reindexed from 1) D137 K139 E141 N142 D155 T171
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A G89 G91 S94 V96 A109 K111 S160 A162 E166 L212 D223 L358 G21 G23 S26 V28 A41 K43 S92 A94 E98 L144 D155 L284
BS02 21O A K76 K115 V127 R131 T148 Q150 L155 F157 K8 K47 V59 R63 T80 Q82 L87 F89 BindingDB: IC50=3.9e+4nM,EC50=85800nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4aw1, PDBe:4aw1, PDBj:4aw1
PDBsum4aw1
PubMed22999883
UniProtO15530|PDPK1_HUMAN 3-phosphoinositide-dependent protein kinase 1 (Gene Name=PDPK1)

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