Structure of PDB 4av6 Chain A

Receptor sequence
>4av6A (length=655) Species: 2336 (Thermotoga maritima) [Search protein sequence]
ALFFLIPLVALGFAAANFAAVVRKISSYIRSGADSFLAHETKAIFKVAIV
IAILLMIFTTWQTGVAFLLGAVMSASAGIVGMKMATRANVRVAEAARTTK
LKVAYQGGSVMGLSVGGFALLGLVLVYLIFGKWMGQVDNLNIYTNWLGIN
FVPFAMTVSGYALGCSIIAMFDRVGGGVYTKAADMAADLIADNVGDNVGD
VAGLGADLLESFVGAIVSSIILASYMFPIYVQKIGENLVHQVPKETIQAL
ISYPIFFALVGLGCSMLGILYVIVKKPSDNPQRELNISLWTSALLTVVLT
AFLTYFYLKDLQGLDVLGFRFGAISPWFSAIIGIFSGILIGFWAEYYTSY
RYKPTQFLGKSSIEGTGMVISNGLSLGMKSVFPPTLTLVLGILFADYFAG
LYGVAIAALGMLSFVATSVSVDSYGPIADNAGGISEVRKITDHLDAVGNT
TAAIGKGFAIGSAIFAALSLFASYMFSQISPSDIGKPPSLVLLLNMLDAR
VIAGALLGAAITYYFSGYLISAVTKAAMIEITSDNALKQMGYPAFIAILT
PLVTGFLLGAEFVGGVLIGTVLSGAMLAILTANSGGAWDNAKKYLEAGNL
EGYGKGSEPHKALVIGDTVGDPLKDTVGPSLDILIKIMSVVSVIAVSIFK
HVHLF
3D structure
PDB4av6 The Structure and Catalytic Cycle of a Sodium-Pumping Pyrophosphatase.
ChainA
Resolution4.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.2.3.1: Na(+)-exporting diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PO4 A D465 D660 K664 D429 D589 K593
BS02 PO4 A D236 N492 D660 D200 N449 D589
BS03 MG A D202 D688 D692 D184 D617 D621
BS04 MG A D232 D465 D196 D429
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004427 inorganic diphosphate phosphatase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0009678 diphosphate hydrolysis-driven proton transmembrane transporter activity
GO:0015081 sodium ion transmembrane transporter activity
GO:0030955 potassium ion binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0006814 sodium ion transport
GO:0035725 sodium ion transmembrane transport
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4av6, PDBe:4av6, PDBj:4av6
PDBsum4av6
PubMed22837527
UniProtQ9S5X0|HPPA_THEMA K(+)-stimulated pyrophosphate-energized sodium pump (Gene Name=hppA)

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