Structure of PDB 4av1 Chain A

Receptor sequence
>4av1A (length=86) Species: 9606 (Homo sapiens) [Search protein sequence]
DKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFS
CFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEA
3D structure
PDB4av1 The Zinc-Finger Domains of Parp1 Cooperate to Recognise DNA Strand-Breaks
ChainA
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A S16 R18 K22 R34 W51 S11 R13 K17 R29 W46
BS02 ZN A C21 H53 C56 C16 H48 C51
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:4av1, PDBe:4av1, PDBj:4av1
PDBsum4av1
PubMed22683995
UniProtP09874|PARP1_HUMAN Poly [ADP-ribose] polymerase 1 (Gene Name=PARP1)

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