Structure of PDB 4as9 Chain A

Receptor sequence
>4as9A (length=213) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
ASETFEFQAEITQLMSLIINTVYSNKEIFLRELISNASDALDKIRYKSLS
DPKQLETEPDLFIRITPKPEQKVLEIRDSGIGMTKAELINNLGTIAKSGT
KAFMEALSAGADVSMIGQFGVGFYSLFLVADRVQVISKSNDDEQYIWESN
AGGSFTVTLDEVNERIGRGTILRLFLKDDQLEYLEEKRIKEVIKRHSEFV
AYPIQLVVTKEVE
3D structure
PDB4as9 Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90.
ChainA
Resolution2.71 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4QS A N37 A41 K44 M84 E88 N92 K98 G121 V122 F124 T171 V213 E214 N36 A40 K43 M83 E87 N91 K97 G120 V121 F123 T170 V212 E213 PDBbind-CN: -logKd/Ki=4.79,Kd=16.3uM
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0051082 unfolded protein binding
GO:0140662 ATP-dependent protein folding chaperone
Biological Process
GO:0006457 protein folding

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Molecular Function
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Biological Process
External links
PDB RCSB:4as9, PDBe:4as9, PDBj:4as9
PDBsum4as9
PubMed23511419
UniProtP02829|HSP82_YEAST ATP-dependent molecular chaperone HSP82 (Gene Name=HSP82)

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