Structure of PDB 4ar1 Chain A

Receptor sequence
>4ar1A (length=381) Species: 1498 (Hathewaya histolytica) [Search protein sequence]
KYCPKTYTFDDGKVIIKAGARVEEEKVKRLYWASKEVNSQFFRVYGIDKP
LEEGNPDDILTMVIYNSPEEYKLNSVLYGYDTNNGGMYIEPEGTFFTYER
EAQESTYTLEELFRHEYTHYLQGRYAVPGQWGRTKLYDNDRLTWYEEGGA
ELFAGSTRTSGILPRKSIVSNIHNTTRNNRYKLSDTVHSKYGASFEFYNY
ACMFMDYMYNKDMGILNKLNDLAKNNDVDGYDNYIRDLSSNHALNDKYQD
HMQERIDNYENLTVPFVADDYLVRHAYKNPNEIYSEISEVAKLKDAKSEV
KKSQYFSTFTLRGSYTGGVSKGKLEDQKAMNKFIDDSLKKLDTYSWSGYK
TLTAYFTNYKVDSSNKVTYDVVFHGYLPNEG
3D structure
PDB4ar1 Structural Basis for Activity Regulation and Substrate Preference of Clostridial Collagenases G, H, and T.
ChainA
Resolution2.01 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.3: microbial collagenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D421 H455 H459 E487 D81 H115 H119 E147
BS02 CA A E430 G463 V467 G469 E90 G123 V127 G129
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4ar1, PDBe:4ar1, PDBj:4ar1
PDBsum4ar1
PubMed23703618
UniProtQ46085|COLH_HATHI Collagenase ColH (Gene Name=colH)

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