Structure of PDB 4aql Chain A

Receptor sequence
>4aqlA (length=442) Species: 9606 (Homo sapiens) [Search protein sequence]
LAHIFRGTFVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEW
CFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTF
PAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITD
KFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKNYSRVKP
IVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYPSY
KNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNSNLSL
SSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKV
NEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSP
IDLFYGDFFGDISEAVIQKFLYLGDDRNIEEVYVGGKQVVPF
3D structure
PDB4aql Pan-Pathway Based Interaction Profiling of Fda-Approved Nucleoside and Nucleobase Analogs with Enzymes of the Human Nucleotide Metabolism.
ChainA
Resolution1.99 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.4.3: guanine deaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H82 H84 H240 D330 H74 H76 H232 D322
BS02 TXC A H84 L99 L100 L103 R213 F214 H240 E243 D246 D330 H76 L91 L92 L95 R205 F206 H232 E235 D238 D322
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0008892 guanine deaminase activity
GO:0016787 hydrolase activity
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0046872 metal ion binding
Biological Process
GO:0000255 allantoin metabolic process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006147 guanine catabolic process
GO:0006161 deoxyguanosine catabolic process
GO:0007399 nervous system development
GO:0043605 amide catabolic process
GO:0046038 GMP catabolic process
GO:0046055 dGMP catabolic process
GO:0046098 guanine metabolic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Cellular Component
External links
PDB RCSB:4aql, PDBe:4aql, PDBj:4aql
PDBsum4aql
PubMed22662200
UniProtQ9Y2T3|GUAD_HUMAN Guanine deaminase (Gene Name=GDA)

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