Structure of PDB 4aq3 Chain A

Receptor sequence
>4aq3A (length=135) Species: 9606 (Homo sapiens) [Search protein sequence]
YDNREIVMKYIHYKLSQRGYEWDVVHLALRQAGDDFSRRYRGDFAEMSSQ
LHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSP
LVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYG
3D structure
PDB4aq3 Identification of a Phenylacylsulfonamide Series of Dual Bcl-2/Bcl-Xl Antagonists.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 398 A F63 Y67 D70 M74 E95 L96 F36 Y40 D43 M47 E68 L69 MOAD: ic50=37nM
PDBbind-CN: -logKd/Ki=7.43,IC50=37nM
BS02 398 A Q58 L160 Y161 G162 Q31 L133 Y134 G135 MOAD: ic50=37nM
PDBbind-CN: -logKd/Ki=7.43,IC50=37nM
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:4aq3, PDBe:4aq3, PDBj:4aq3
PDBsum4aq3
PubMed22608961
UniProtP10415|BCL2_HUMAN Apoptosis regulator Bcl-2 (Gene Name=BCL2);
Q07817|B2CL1_HUMAN Bcl-2-like protein 1 (Gene Name=BCL2L1)

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