Structure of PDB 4ap6 Chain A

Receptor sequence
>4ap6A (length=389) Species: 9606 (Homo sapiens) [Search protein sequence]
SRRRYLLYDVNPPAGFNLRRDVYIRIASLLKTLLKTEEWVLVLPPWGRLY
HWQSPDIHQVRIPWSEFFDLPSLNKNIPVIEYEQFIAESGGPFIDQVYVL
QSYAEGWKEGTWEEKVDERPCIDQLLYSQDKHEYYRGWFWGYEETRGLNV
SCLSVQGSASIVAPLLLRNTSARSVMLDRAENLLHDHYGGKEYWDTRRSM
VFARHLREVGDEFRSRHLNSTDDADRIPFQEDWMKMKVKLGSALGGPYLG
VHLRRKDFIWGHRQDVPSLEGAVRKIRSLMKTHRLDKVFVATDAVRKEYE
ELKKLLPEMVRFEPTWEELELYKDGGVAIIDQWICAHARFFIGTSVSTFS
FRIHEEREILGLDPKTTYNRFCGDQEKACEQPTHWKITY
3D structure
PDB4ap6 Structure of Human Pofut2: Insights Into Thrombospondin Type 1 Repeat Fold and O-Fucosylation.
ChainA
Resolution3.401 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.221: peptide-O-fucosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GFB A P53 G55 N57 H292 R294 T332 V367 A368 D371 T388 F389 P13 G15 N17 H252 R254 T292 V327 A328 D331 T348 F349
Gene Ontology
Molecular Function
GO:0008417 fucosyltransferase activity
GO:0016757 glycosyltransferase activity
GO:0046922 peptide-O-fucosyltransferase activity
Biological Process
GO:0001707 mesoderm formation
GO:0006004 fucose metabolic process
GO:0006486 protein glycosylation
GO:0010468 regulation of gene expression
GO:0010717 regulation of epithelial to mesenchymal transition
GO:0036065 fucosylation
GO:0036066 protein O-linked fucosylation
GO:0051046 regulation of secretion
GO:1903334 positive regulation of protein folding
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4ap6, PDBe:4ap6, PDBj:4ap6
PDBsum4ap6
PubMed22588082
UniProtQ9Y2G5|OFUT2_HUMAN GDP-fucose protein O-fucosyltransferase 2 (Gene Name=POFUT2)

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