Structure of PDB 4ap3 Chain A

Receptor sequence
>4ap3A (length=521) Species: 1829 (Rhodococcus rhodochrous) [Search protein sequence]
TSYDVVVVGAGIAGLYAIHRFRSQGLTVRAFEAASGVGGVWYWNRYPGAR
CDVESIDYSYSFSPELEQEWNWSEKYATQPEILAYLEHVADRFDLRRDIR
FDTRVTSAVLDEEGLRWTVRTDRGDEVSARFLVVAAGPLSNANTPAFDGL
DRFTGDIVHTARWPHDGVDFTGKRVGVIGTGSSGIQSIPIIAEQAEQLFV
FQRSANYSIPAGDDATRAEQKANYAERRRLSRESGGGSPHRPHPKSALEV
SEEERRAVYEERWKLGGVLFSKAFPDQLTDPAANDTARAFWEEKIRAVVD
DPAVAELLTPKDHAIGAKRIVLDSGYYETYNRDNVELVDLRSTPIVGMDE
TGIVTTGAHYDLDMIVLATGFDAMTGSLDKLEIVGRGGRTLKETWAAGPR
TYLGLGIDGFPNFFNLTGPGSPSVLANMVLHSELHVDWVADAIAYLDARG
AAGIEGTPEAVADWVEECRNRAEASLLNSANSWYLGANRVFMPFLGGFGV
YREIITEVAESGYKGFAILEG
3D structure
PDB4ap3 Exploring the Structural Basis of Substrate Preferences in Baeyer-Villiger Monooxygenases: Insight from Steroid Monooxygenase.
ChainA
Resolution2.39 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.13.54: ketosteroid monooxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A V27 G28 G30 A32 E51 A52 G58 V59 W60 R69 C70 D71 V72 Y77 R123 V124 A155 G156 P157 L158 N450 M451 V8 G9 G11 A13 E32 A33 G39 V40 W41 R50 C51 D52 V53 Y58 R104 V105 A136 G137 P138 L139 N427 M428
BS02 NAP A D71 S201 R342 G393 F394 W506 D52 S182 R319 G370 F371 W483
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004497 monooxygenase activity
GO:0004499 N,N-dimethylaniline monooxygenase activity
GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding

View graph for
Molecular Function
External links
PDB RCSB:4ap3, PDBe:4ap3, PDBj:4ap3
PDBsum4ap3
PubMed22605340
UniProtO50641

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