Structure of PDB 4ap0 Chain A

Receptor sequence
>4ap0A (length=325) Species: 9606 (Homo sapiens) [Search protein sequence]
KNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLSRKTYTFDM
VFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERS
PNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFD
LLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAK
RTTAATLMNAYSSRSHSVFSVTIHMKEVKIGKLNLVDLAGSENIGRINQS
LLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASL
NLEETLSTLEYAHRAKNILNKPEVN
3D structure
PDB4ap0 The Structure of the Ternary Eg5-Adp-Ispinesib Complex
ChainA
Resolution2.594 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A R26 P27 T107 G108 G110 K111 T112 F113 R10 P11 T87 G88 G90 K91 T92 F93
BS02 G7X A E116 G117 E118 R119 W127 I136 P137 L160 Y211 L214 G217 R221 E96 G97 E98 R99 W107 I116 P117 L140 Y191 L194 G197 R201 PDBbind-CN: -logKd/Ki=8.00,Kd<10nM
BindingDB: Ki=2.3nM,IC50=47nM
BS03 ADP A L30 K34 L14 K18
Gene Ontology
Molecular Function
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0008017 microtubule binding
Biological Process
GO:0007018 microtubule-based movement

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Molecular Function
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Biological Process
External links
PDB RCSB:4ap0, PDBe:4ap0, PDBj:4ap0
PDBsum4ap0
PubMed22993085
UniProtP52732|KIF11_HUMAN Kinesin-like protein KIF11 (Gene Name=KIF11)

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