Structure of PDB 4aov Chain A

Receptor sequence
>4aovA (length=401) Species: 84980 (Desulfotalea psychrophila) [Search protein sequence]
MKIQMKTPLVELDGDEMTRVLWPLIKDKLLLPFIDLQTEYYDLGIEERDR
TNDQITIDAAEAIKKYGVGVKNATITPNQDRVEEYGLKEQWKSPNATVRA
MLDGTVFRKPIMVKNIKPSVRSWQKPIVVGRHAYGDFYKNAEIFAEAGGK
LEIVVTDKNGKETRQTIMEVDEPAIVQGIHNTVASIGHFARACFEYSLDQ
KIDCWFATKDTISKQYDQRFKIIFEEIFAQEYKEKFAAAGIEYFYTLIDD
VVARMMKTEGGMLWACKNYDGDVMSDMVASAFGSLAMMSSVLVSPYGYFE
YEAAHGTVQRHYYQHLKGERTSTNPVALIYAWTGALRKRGELDGTPDLCA
FCDSLEAITIECIESGYMTGDLARICEPAAIKVLDSIEFIDELGKRLQQL
K
3D structure
PDB4aov The Complex Structures of Isocitrate Dehydrogenase from Clostridium Thermocellum and Desulfotalea Psychrophila Suggest a New Active Site Locking Mechanism
ChainA
Resolution1.93 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.42: isocitrate dehydrogenase (NADP(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP A A73 T74 R81 N95 L285 A286 H305 G306 T307 V308 R310 H311 T323 N324 A73 T74 R81 N95 L285 A286 H305 G306 T307 V308 R310 H311 T323 N324
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004450 isocitrate dehydrogenase (NADP+) activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0046872 metal ion binding
GO:0051287 NAD binding
Biological Process
GO:0006099 tricarboxylic acid cycle
GO:0006102 isocitrate metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4aov, PDBe:4aov, PDBj:4aov
PDBsum4aov
PubMed23650595
UniProtQ6AQ66

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