Structure of PDB 4amj Chain A

Receptor sequence
>4amjA (length=287) Species: 9103 (Meleagris gallopavo) [Search protein sequence]
GAELLSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFIT
SLACADLVVGLLVVPFGATLVVRGTWLWGSFLCELWTSLDVLCVTASIET
LCVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHW
WRDEDPQALKCYQDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVALRVY
REAKEQSRVMLMREHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDLVP
DWLFVAFNWLGYANSAMNPIIYCRSPDFRKAFKRLLA
3D structure
PDB4amj Crystal Structures of a Stabilized Beta1-Adrenoceptor Bound to the Biased Agonists Bucindolol and Carvedilol
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CVD A W117 D121 V122 F201 S211 F306 F307 N310 N329 Y333 W86 D90 V91 F170 S180 F235 F236 N239 N258 Y262
BS02 2CV A M48 W330 M17 W259
BS03 2CV A W181 N204 W150 N173
BS04 2CV A R205 F315 R174 F244
BS05 2CV A V160 T164 V129 T133
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004935 adrenergic receptor activity
GO:0004940 beta1-adrenergic receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0045823 positive regulation of heart contraction
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:4amj, PDBe:4amj, PDBj:4amj
PDBsum4amj
PubMed22579251
UniProtP07700|ADRB1_MELGA Beta-1 adrenergic receptor (Gene Name=ADRB1)

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