Structure of PDB 4alg Chain A

Receptor sequence
>4algA (length=118) Species: 9606 (Homo sapiens) [Search protein sequence]
PGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPM
DMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEK
IFLQKVASMPQEEQELVV
3D structure
PDB4alg Identification of a Novel Series of Bet Family Bromodomain Inhibitors: Binding Mode and Profile of I-Bet151 (Gsk1210151A).
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1GH A W51 P52 F53 V57 L62 N110 I116 M119 W26 P27 F28 V32 L37 N85 I91 M94 MOAD: ic50=0.5uM
PDBbind-CN: -logKd/Ki=6.30,IC50=0.50uM
BindingDB: IC50=501.19nM,Kd=70nM,Ki=50nM
External links
PDB RCSB:4alg, PDBe:4alg, PDBj:4alg
PDBsum4alg
PubMed22437115
UniProtP25440|BRD2_HUMAN Bromodomain-containing protein 2 (Gene Name=BRD2)

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