Structure of PDB 4aj3 Chain A

Receptor sequence
>4aj3A (length=416) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVD
AAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIK
GPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMV
IFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP
CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR
EEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA
CMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDK
VNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGA
KLLKCSEFGDAIIENM
3D structure
PDB4aj3 Induced Fit and the Catalytic Mechanism of Isocitrate Dehydrogenase.
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y160 K230 D283 D307 D311
Catalytic site (residue number reindexed from 1) Y160 K230 D283 D307 D311
Enzyme Commision number 1.1.1.42: isocitrate dehydrogenase (NADP(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP A P102 L103 T105 N115 I320 E336 H339 G340 T341 A342 Y345 V351 N352 Y391 D392 P102 L103 T105 N115 I320 E336 H339 G340 T341 A342 Y345 V351 N352 Y391 D392
BS02 CA A D307 D311 D307 D311
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004450 isocitrate dehydrogenase (NADP+) activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0046872 metal ion binding
GO:0051287 NAD binding
GO:0097216 guanosine tetraphosphate binding
Biological Process
GO:0006097 glyoxylate cycle
GO:0006099 tricarboxylic acid cycle
GO:0006979 response to oxidative stress
GO:0022900 electron transport chain
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4aj3, PDBe:4aj3, PDBj:4aj3
PDBsum4aj3
PubMed22891681
UniProtP08200|IDH_ECOLI Isocitrate dehydrogenase [NADP] (Gene Name=icd)

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