Structure of PDB 4agn Chain A

Receptor sequence
>4agnA (length=197) Species: 9606 (Homo sapiens) [Search protein sequence]
SVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKLFCQLAKTCPVQL
WVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLI
RVEGNLRAEYLDDRNTFRHSVVVPCEPPEVGSDCTTIHYNYMCYSSCMGG
MNRRPILTIITLEDSSGNLLGRDSFEVRVCACPGRDRRTEEENLRKK
3D structure
PDB4agn Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant P53.
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C176 H179 C238 C242 C81 H84 C143 C147
BS02 NXG A L145 V147 D148 T150 P151 P152 P153 C220 P222 P223 T230 L50 V52 D53 T55 P56 P57 P58 C125 P127 P128 T135 MOAD: Kd=107uM
PDBbind-CN: -logKd/Ki=3.97,Kd=107uM
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006915 apoptotic process
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4agn, PDBe:4agn, PDBj:4agn
PDBsum4agn
PubMed22439615
UniProtP04637|P53_HUMAN Cellular tumor antigen p53 (Gene Name=TP53)

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