Structure of PDB 4af3 Chain A

Receptor sequence
>4af3A (length=253) Species: 9606 (Homo sapiens) [Search protein sequence]
RHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVE
HQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKS
CTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADF
GLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRI
VKVDLKFPASVPTGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVL
PPS
3D structure
PDB4af3 Crystal Structure of Human Aurora B in Complex with Incenp and Vx-680.
ChainA
Resolution2.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D200 K202 E204 N205 D218
Catalytic site (residue number reindexed from 1) D131 K133 E135 N136 D149
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VX6 A L83 F88 V91 A104 K106 E155 Y156 A157 P158 G160 L207 L14 F19 V22 A35 K37 E86 Y87 A88 P89 G91 L138 PDBbind-CN: -logKd/Ki=7.51,IC50=31nM
BindingDB: Ki=18nM,IC50=30nM,Kd=7.4nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4af3, PDBe:4af3, PDBj:4af3
PDBsum4af3
PubMed22920039
UniProtQ96GD4|AURKB_HUMAN Aurora kinase B (Gene Name=AURKB)

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