Structure of PDB 4abk Chain A

Receptor sequence
>4abkA (length=182) Species: 9606 (Homo sapiens) [Search protein sequence]
MFYGTVSSPDSGVYEMKIGSIIFQVASGDITKEEADVIVNSTSNSFNLKA
GVSKAILECAGQNVERECSQQAQQRKNDYIITGGGFLRCKNIIHVIGGND
VKSSVSSVLQECEKKNYSSICLPAIGTGNAKQHPDKVAEAIIDAIEDFVQ
KGSAQSVKKVKVVIFLPQVLDVFYANMKKREG
3D structure
PDB4abk Recognition of Mono-Adp-Ribosylated Artd10 Substrates by Artd8 Macrodomains
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AR6 A D1235 I1236 S1247 T1248 L1254 G1257 V1258 G1303 G1304 G1332 T1333 G1334 N1335 A1336 F1371 D29 I30 S41 T42 L48 G51 V52 G97 G98 G126 T127 G128 N129 A130 F165 PDBbind-CN: -logKd/Ki=5.72,Kd=1.9uM
External links
PDB RCSB:4abk, PDBe:4abk, PDBj:4abk
PDBsum4abk
PubMed23473667
UniProtQ460N5|PAR14_HUMAN Protein mono-ADP-ribosyltransferase PARP14 (Gene Name=PARP14)

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