Structure of PDB 4aaa Chain A

Receptor sequence
>4aaaA (length=295) Species: 9606 (Homo sapiens) [Search protein sequence]
LYFQSMEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVK
KIAMREIKLLKQLRHENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFP
NGLDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDF
GFAEVATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSD
IDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRLPEIKEREPLERRYPKLS
EVVIDLAKKCLHIDPDKRPFCAELLHHDFFQMDGFAERFSQELQL
3D structure
PDB4aaa CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function.
ChainA
Resolution1.53 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D126 K128 E130 N131 D144 T164
Catalytic site (residue number reindexed from 1) D131 K133 E135 N136 D149 T157
Enzyme Commision number 2.7.11.22: cyclin-dependent kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DKI A V10 Y15 V18 A31 F82 V83 D84 T86 D89 L133 C143 D144 V15 Y20 V23 A36 F87 V88 D89 T91 D94 L138 C148 D149
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4aaa, PDBe:4aaa, PDBj:4aaa
PDBsum4aaa
PubMed29420175
UniProtQ92772|CDKL2_HUMAN Cyclin-dependent kinase-like 2 (Gene Name=CDKL2)

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