Structure of PDB 4a9l Chain A

Receptor sequence
>4a9lA (length=126) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTE
3D structure
PDB4a9l Fragment-Based Discovery of Bromodomain Inhibitors Part 1: Inhibitor Binding Modes and Implications for Lead Discovery.
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 P9L A W81 P82 F83 V87 L92 L94 Y139 N140 I146 M149 W40 P41 F42 V46 L51 L53 Y98 N99 I105 M108 BindingDB: IC50=30000nM
External links
PDB RCSB:4a9l, PDBe:4a9l, PDBj:4a9l
PDBsum4a9l
PubMed22136404
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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