Structure of PDB 4a9i Chain A

Receptor sequence
>4a9iA (length=110) Species: 9606 (Homo sapiens) [Search protein sequence]
VTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMG
TIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFL
QKVASMPQEE
3D structure
PDB4a9i Fragment-Based Discovery of Bromodomain Inhibitors Part 1: Inhibitor Binding Modes and Implications for Lead Discovery.
ChainA
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 P9I A W97 V103 L108 N156 I162 W23 V29 L34 N82 I88 PDBbind-CN: -logKd/Ki=4.90,IC50=12.6uM
External links
PDB RCSB:4a9i, PDBe:4a9i, PDBj:4a9i
PDBsum4a9i
PubMed22136404
UniProtP25440|BRD2_HUMAN Bromodomain-containing protein 2 (Gene Name=BRD2)

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