Structure of PDB 4a5y Chain A

Receptor sequence
>4a5yA (length=334) Species: 9606 (Homo sapiens) [Search protein sequence]
KNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTY
TFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTME
GERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNE
ELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEK
GAAKRTTAATLMNAYSSRSHSVFSVTIHMKETEELVKIGKLNLVDLAGSE
NRAREAGNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTR
TSIIATISPASLNLEETLSTLEYAHRAKNILNKP
3D structure
PDB4a5y Snapshots" of Ispinesib-Induced Conformational Changes in the Mitotic Kinesin Eg5.
ChainA
Resolution2.45 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A R24 R26 P27 G108 G110 T112 F113 E118 R8 R10 P11 G92 G94 T96 F97 E102
BS02 G7X A E116 G117 E118 W127 I136 P137 L160 Y211 L214 G217 R221 E100 G101 E102 W111 I120 P121 L144 Y195 L198 G201 R205 BindingDB: Ki=2.3nM,IC50=47nM
Gene Ontology
Molecular Function
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0008017 microtubule binding
Biological Process
GO:0007018 microtubule-based movement

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4a5y, PDBe:4a5y, PDBj:4a5y
PDBsum4a5y
PubMed23658017
UniProtP52732|KIF11_HUMAN Kinesin-like protein KIF11 (Gene Name=KIF11)

[Back to BioLiP]