Structure of PDB 4a5r Chain A

Receptor sequence
>4a5rA (length=257) Species: 1402 (Bacillus licheniformis) [Search protein sequence]
KDDFAKLEEQFDAKLGIFALDTGTNRTVTYRPDERFAFASTIKALTVGVL
LQQKSIEDLNQRITYTRDDLVNYNPITEKHVDTGMTLKELADASLRYSDN
TAQNLILKQIGGPESLKKELRKIGDEVTNPERFEPELNEVNPGETQDTST
ARALATSLQAFALEDKLPSEKRELLIDWMKRNTTGDALIRAGVPEGWEVA
DKTGAGSYGTRNDIAIIWPPKGDPVVLAVLSSRDKKDAKYDDKLIAEATK
VVVKALN
3D structure
PDB4a5r Crystal Structure of Class a Beta-Lactamase from Bacillus Licheniformis Inhibited by Tazobactam
ChainA
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S70 K73 S130 E166 K234 A237
Catalytic site (residue number reindexed from 1) S40 K43 S98 E134 K202 A205
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TBE A S70 N104 N170 G236 A237 G238 S40 N72 N138 G204 A205 G206
Gene Ontology
Molecular Function
GO:0008800 beta-lactamase activity
GO:0016787 hydrolase activity
Biological Process
GO:0017001 antibiotic catabolic process
GO:0030655 beta-lactam antibiotic catabolic process
GO:0046677 response to antibiotic

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Molecular Function
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Biological Process
External links
PDB RCSB:4a5r, PDBe:4a5r, PDBj:4a5r
PDBsum4a5r
PubMed
UniProtP94458

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