Structure of PDB 4a55 Chain A

Receptor sequence
>4a55A (length=1001) Species: 10090 (Mus musculus) [Search protein sequence]
PSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLVTIKHELFREAR
KYPLHQLLQDETSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEP
VGNREEKILNREIGFVIGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLR
DLNSPHSRAMYVYPPNVESSPELPKHIYNKLDKGQIIVVIWVIVSPNNDK
QKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLKLCVLEYQGKYILKV
CGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPIDSFTM
PSYSRSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGIYHGGEPL
CDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVCPLAWGNI
NLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEF
DWFSSVVKFPDMSVIEEHANWSVNDKEQLRALCTRDPLSEITEQEKDFLW
SHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAMELL
DCNYPDPMVRSFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRF
LLKKALTNQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHL
NRQVEAMEKLINLTDILKQEKKDETQKVQMKFLVEQMRQPDFMDALQGFL
SPLNPAHQLGNLRLEECRIMSSAKRPLWLNWENPDIMSELLFQNNEIIFK
NGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVR
NSHTIMQIQCQFNSHTLHQWLKDKNKGEIYDAAIDLFTRSCAGYCVATFI
LGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQEYTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGM
PELQSFDDIAYIRKTLALDKTEQEALEYFTKQMNDAHHGGWTTKMDWIFH
T
3D structure
PDB4a55 Regulation of Lipid Binding Underlies the Activation Mechanism of Class Ia Pi3-Kinases.
ChainA
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
2.7.1.137: phosphatidylinositol 3-kinase.
2.7.1.153: phosphatidylinositol-4,5-bisphosphate 3-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 P08 A M772 I848 E849 V851 I932 M720 I796 E797 V799 I872
BS02 P08 A C905 F954 T957 F960 F980 Q981 M1043 C845 F894 T897 F900 F920 Q921 M983
Gene Ontology
Molecular Function
GO:0004674 protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0030295 protein kinase activator activity
GO:0043560 insulin receptor substrate binding
GO:0044024 histone H2AS1 kinase activity
GO:0046934 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0106310 protein serine kinase activity
Biological Process
GO:0001525 angiogenesis
GO:0001889 liver development
GO:0006006 glucose metabolic process
GO:0006909 phagocytosis
GO:0008286 insulin receptor signaling pathway
GO:0010468 regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0014823 response to activity
GO:0014870 response to muscle inactivity
GO:0016310 phosphorylation
GO:0030036 actin cytoskeleton organization
GO:0030835 negative regulation of actin filament depolymerization
GO:0032869 cellular response to insulin stimulus
GO:0035994 response to muscle stretch
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
GO:0038084 vascular endothelial growth factor signaling pathway
GO:0038203 TORC2 signaling
GO:0040014 regulation of multicellular organism growth
GO:0043201 response to L-leucine
GO:0043457 regulation of cellular respiration
GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO:0043524 negative regulation of neuron apoptotic process
GO:0046854 phosphatidylinositol phosphate biosynthetic process
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO:0055119 relaxation of cardiac muscle
GO:0060612 adipose tissue development
GO:0071333 cellular response to glucose stimulus
GO:0071464 cellular response to hydrostatic pressure
GO:0071548 response to dexamethasone
GO:0086003 cardiac muscle cell contraction
GO:0097009 energy homeostasis
GO:0110053 regulation of actin filament organization
GO:0141068 autosome genomic imprinting
GO:1903544 response to butyrate
GO:1905477 positive regulation of protein localization to membrane
GO:2000270 negative regulation of fibroblast apoptotic process
GO:2000811 negative regulation of anoikis
Cellular Component
GO:0005829 cytosol
GO:0005942 phosphatidylinositol 3-kinase complex
GO:0005943 phosphatidylinositol 3-kinase complex, class IA
GO:0014704 intercalated disc
GO:0030027 lamellipodium

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4a55, PDBe:4a55, PDBj:4a55
PDBsum4a55
PubMed22120714
UniProtP42337|PK3CA_MOUSE Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Gene Name=Pik3ca)

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