Structure of PDB 4a51 Chain A

Receptor sequence
>4a51A (length=322) Species: 9606 (Homo sapiens) [Search protein sequence]
NIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYT
FDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEG
ERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEE
LFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKG
AAKRTTAATLMNAYSSRSHSVFSVTIHMKLVKIGKLNLVDLAGSENINQS
LLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASL
NLEETLSTLEYAHRAKNILNKP
3D structure
PDB4a51 Triphenylbutanamines: Kinesin Spindle Protein Inhibitors with in Vivo Antitumor Activity.
ChainA
Resolution2.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A R24 R26 P27 G108 G110 K111 T112 F113 E118 R7 R9 P10 G91 G93 K94 T95 F96 E101
BS02 MG A T112 D265 T95 D240
BS03 DQ8 A E116 G117 E118 R119 P137 Y211 A218 R221 E99 G100 E101 R102 P120 Y194 A201 R204 PDBbind-CN: -logKd/Ki=6.73,Ki=185.8nM
BindingDB: Ki=185.8nM
Gene Ontology
Molecular Function
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0008017 microtubule binding
Biological Process
GO:0007018 microtubule-based movement

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Molecular Function
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Biological Process
External links
PDB RCSB:4a51, PDBe:4a51, PDBj:4a51
PDBsum4a51
PubMed22248262
UniProtP52732|KIF11_HUMAN Kinesin-like protein KIF11 (Gene Name=KIF11)

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